There are many things you should do and many things to avoid doing while podcasting. You need to stay on the topic you talking about. This only pertains if you have other people you are podcasting and that is to make sure that you have everyone talk and make it like a discussion. Never make the podcast too long, people will get bored and lose interest. You an get the audience involved by putting a poll and showing the results the next episode. You can include PowerPoint to make it visual also. There are so many possibilities.